Scientific Research & Clinical Studies on FPP®

Fermented Papaya Preparation

The Osato Research Institute (ORI) is a non-profit organization founded in 2004 and based in Gifu, Japan. ORI conducts and coordinates scientific programs and clinical studies that focus on our natural defense systems, healthy living, healthy aging, and Osato ‘fermented papaya preparation’ or FPP®, commercially known as Immun’Âge®.

World-renowned scientists have been studying FPP® properties and as members of our scientific board, they have contributed to scientifically prove the effects of FPP® on the immune system, the antioxidative system, and the production of cellular energy.

Our members come from very different fields and many different countries. They communicate their research findings on FPP® at international academic conferences, at ORI scientific committee meetings, and in scientific journals.

We are presenting below the main research and studies that have been done on FPP®

Publications and references available on Medline (PubMed) and at

International scientific recognition

  • "FPP® has remarkable properties to combat oxidative stress and to stimulate the immune system."

    Prof. Luc Montagnier
    2008 Nobel Prize of Medicine
    President of the World AIDS foundation

  • "We studied FPP® at the University of Southern California in our laboratories and demonstrated its antioxidant properties, but also a very important action of improving the immune system."

    Prof. Lester Packer
    University of Southern California Health Center, PhD

  • "Papaya is rich in antioxidants and we recently know the importance of the protection provided by antioxidants in our body. We compared five different fruits and two vegetables and found papaya to be the most antioxidant-rich tropical fruit."

    Dr. Mark E. Weksler
    Professor Emeritus of Medicine, 
    Weill Cornell Medical College

  • "In a preliminary study, on 12 patients suffering from thalassemia, the FPP® by its antioxidant action allowed a decrease in oxygenated free radicals as well as an increase in the level of glutathione in both red blood cells and platelets."

    Dr. Eliezer Rachmilewitz
    Hebrew University 
    Medical Center, Jerusalem


Immuno-stimulating properties: 
  • Actions of FPP® on the cells of the immune system | Pr. Lester Packer | ISBN 2-7046-1675-2
  • Nitric oxide synthesis and TNF-secretion in RAW 264.7 macrophages | G. Rimbach & co | PMID: 12659174
Anti-oxidative properties:
  • Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype. A Randomized, Placebo-Controlled, Cross-Over Study. | F. Marotta & Co | PMID: 16804018
  • Advantages of Fermented Papaya on our health: Beneficial effects on oxidative stress and immunity: oxidative stress and chronic diseases. | Pr. Luc Montagnier | ISBN 2-7046-1675-2
On cellular energy production: 
  • Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients. | Ryan Dickerson & co | PMID:25268638

The combination of these three properties makes Immun'Âge® a powerful healthy aging ally.